Prognostic significance of HIF1-α immunohistochemical expression in gliomas and it's relation to IDH1 mutation status

Abstract Background Gliomas are the commonest primary adults’ brain tumors. Hypoxia performs an essential role in gliomas’ initiation as well progression through hypoxia inducible factor (HIF-1α) activation, which could serve a promising target treatment of gliomas. Our study aimed to evaluate types and grades glioma cases detect isocitrate dehydrogenase 1 (IDH1) mutation status expression HIF-1α all included its correlation with clinical data pathological parameters. Results Samples from 71 patients who were diagnosed studied immunohistochemically for IDH1-R132H (if indicated) expression. Expression was detected 73.2% significantly increased older patients, high-grade gliomas tumors positive necrosis. We IDH1 histologically grade 2, 3and 4 astrocytic oligodendroglial (51 out gliomas). immunohistochemical 62.7% cases. higher younger age. noted also lower tumor grade. A statistically significant relation between negative high level Conclusion Absence among suggesting both predicting indicators poor prognosis.